Flow Chemistry

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Which Is the Problem to Be Solved ?

Batch processing, the most usual production scheme in the pharmaceutical and fine chemicals industries, presents important disadvantages:

  • Low intensification
  • Waste generation
  • Risks associated to large volumes
  • Problems in scale-up

Flow Processing as a Convenient Alternative

From the microfluidic to the mesofluidic scale, flow processing solves most of the problems associated to batch processing:

  • Large productions can be achieved with small reactors (intensification)
  • Production can be instantaneously adapted to needs
  • Risks are minimized
  • Waste is minimized
  • Scale-up is straightforward

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Flow techniques are slowly becoming mainstream practice. This entails that every day more and more labs, in academia or industry, possess a small collection of pumps and other related gadgets that a few years ago most chemists would have never dreamt of using. We can offer these chemists our know-how, expertise and technologies in this field to optimize your process.

Which are the Advantages of Flow Techniques?

Flow techniques present a series of advantages that make them a very convenient alternative for the production of organic compounds:

  • Faster mixing
  • Increased heat transfer (avoids exotherms and runaway reactions)
  • Reactions with temperature-dependent selectivity issues are more easily controlled
  • Improved safety profile (even in the worst case, the reacting volumes are so small that possible damages are limited)
  • Process intensification (reduced footprint, increased sustainability profile)
  • Flexible production
  • Facilitates optimization of reaction conditions (saving time and volume of reagents)
  • Amenable for automation

ERTFLOW: your batch to flow partner!

We have detailed below a representative list of some of the reactions carried out in continuous flow in our lab:

  • Aldol and cross-aldol reactions
  • α-Aminoxylation of aldehydes and ketones
  • Syn– and anti-Mannich reactions
  • Three-component anti-Mannich reactions
  • Michael additions
  • Domino Michael-Knoevenagel reaction
  • α-Amination of aldehydes
  • Friedel-Crafts alkylation & aza-Friedel-Crafts reactions
  • Aziridinations
  • Epoxidations
  • Allylic amination
  • Alcohol oxydations
  • Carboxylation
  • Photoredox reactions
  • Carbene transfer reactions

Let us show you an example (Click on the video)